HIRSCHMANN, RALPH: search on Z-Library

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1

Nonpeptidal peptidomimetics with .beta.-D-glucose scaffolding. A partial somatostatin agonist bearing a close structural relationship to a potent, selective substance P antagonist

Hirschmann, Ralph, Nicolaou, K. C., Pietranico, Sherrie, Salvino, Joseph, Leahy, Ellen M., Sprengeler, Paul A., Furst, George, Strader, Catherine D., Smith, Amos B.

Journal:

Journal of the American Chemical Society

Year:

1992

Language:

english

File:

PDF, 290 KB

english, 1992

2

Total synthesis of an enzyme. V. Preparation of enzymatically active material

Hirschmann, Ralph, Nutt, Ruth F., Veber, Daniel F., Vitali, Ronald A., Varga, Sandor L., Jacob, Theodore A., Holly, Frederick W., Denkewalter, Robert G.

Journal:

Journal of the American Chemical Society

Year:

1969

Language:

english

File:

PDF, 292 KB

english, 1969

3

Design, Synthesis, and Biological Evaluation of Monopyrrolinone-Based HIV-1 Protease Inhibitors

Smith, Amos B., Cantin, Louis-David, Pasternak, Alexander, Guise-Zawacki, Lisa, Yao, Wenquin, Charnley, Adam K., Barbosa, Joseph, Sprengeler, Paul A., Hirschmann, Ralph, Munshi, Sanjeev, Olsen, David

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 482 KB

english, 2003

4

Enantioretentive alkylation of oxazolidinone aluminum enolates with epoxides: Preparation of uncoded homoserine analogs

Amos B. Smith III, Alexander Pasternak, Akihisa Yokoyama, Ralph Hirschmann

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 276 KB

english, 1994

5

Transport Characteristics of Peptidomimetics. Effect of the Pyrrolinone Bioisostere on Transport Across Caco-2 Cell Monolayers

Masao Sudoh, Giovanni M. Pauletti, Wenqing Yao, William Moser, Akihisa Yokoyama, Alexander Pasternak, Paul A. Sprengeler, Amos B. Smith, Ralph Hirschmann, Ronald T. Borchardt

Journal:

Pharmaceutical Research

Year:

1998

File:

PDF, 644 KB

1998

6

A Second-Generation Synthesis of Polypyrrolinone Nonpeptidomimetics: Prelude to the Synthesis of Polypyrrolinones on Solid Support

Smith, Amos B., Liu, Hu, Hirschmann, Ralph

Journal:

Organic Letters

Year:

2000

Language:

english

File:

PDF, 129 KB

english, 2000

7

Controlled synthesis of peptides in aqueous medium. III. Use of Leuch's anhydrides in the synthesis of di-peptides. Mechanism and control of side reactions

Hirschmann, Ralph F.

Journal:

Journal of Organic Chemistry

Year:

1967

Language:

english

File:

PDF, 2.34 MB

english, 1967

8

Azide and Cyanide Displacements via Hypervalent Silicate Intermediates.

Soli, Eric D., Manoso, Amy S., Patterson, Michael C., DeShong, Philip, Favor, David A., Hirschmann, Ralph, Smith, Amos B.

Journal:

Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 152 KB

english, 1999

9

Total synthesis of an enzyme. I. Objective and strategy

Denkewalter, Robert G., Veber, Daniel F., Holly, Frederick W., Hirschmann, Ralph

Journal:

Journal of the American Chemical Society

Year:

1969

Language:

english

File:

PDF, 286 KB

english, 1969

10

The synthesis of peptides in aqueous medium, IV. A novel protecting group for cysteine

Daniel F. Veber, John D. Milkowski, Robert G. Denkewalter, Ralph Hirschmann

Journal:

Tetrahedron Letters

Year:

1968

Language:

english

File:

PDF, 123 KB

english, 1968

11

Review of the Fogarty International Center Conference, NIH: Peptides in Health and Disease

RALPH HIRSCHMANN

Journal:

Chemical Biology & Drug Design

Year:

1992

Language:

english

File:

PDF, 551 KB

english, 1992

12

Synthesis of peptides in aqueous medium. V. Preparation and use of 2,5-thiazolidinediones (NTA's). Use of the 13C-H nuclear magnetic resonance signal as internal standard for quantitative studies

Dewey, R. S., Schoenewaldt, E. F., Joshua, H., Paleveda, William J., Schwam, H., Barkemeyer, H., Arison, Byron H., Veber, Daniel F., Denkewalter, Robert G., Hirschmann, Ralph.

Journal:

Journal of the American Chemical Society

Year:

1968

Language:

english

File:

PDF, 279 KB

english, 1968

13

Characterization of synthetic parathyroid hormone analogs and of synthetic by-products

Caporale, Lynn, Nutt, Ruth, Levy, Jay, Smith, Jack, Arison, Byron, Bennett, Carl, Albers-Schonberg, Georg, Pitzenberger, Steven, Rosenblatt, Michael, Hirschmann, Ralph

Journal:

Journal of Organic Chemistry

Year:

1989

Language:

english

File:

PDF, 501 KB

english, 1989

14

Efficacy of Water-Soluble Derivatives of Vitamin K1 in Counteracting Drug-Induced Hypoprothrombinemia

MUSHETT, CHARLES W., KELLEY, KANE L., HIRSCHMANN, RALPH

Journal:

Year:

1959

File:

PDF, 1.21 MB

1959

15

The synthesis of an enzyme

Ralph Hirschmann, Robert G. Denkewalter

Journal:

Naturwissenschaften (The Science of Nature)

Year:

1970

Language:

english

File:

PDF, 887 KB

english, 1970

16

Novel Chimeric Scaffolds to Extend the Exploration of Receptor Space: Hybrid β-d-Glucose−Benzoheterodiazepine Structures for Broad Screening. Effect of Amide Alkylation on the Course of Cyclization Reactions

Abrous, Leïla, Jokiel, Patrick A., Friedrich, Sarah R., Hynes,, John, Smith, Amos B., Hirschmann, Ralph

Journal:

Journal of Organic Chemistry

Year:

2004

Language:

english

File:

PDF, 521 KB

english, 2004

17

Total synthesis of an enzyme. IV. Factors affecting the conversion of protected S-protein to ribonuclease S'

Veber, Daniel F., Varga, Sandor L., Milkowski, John D., Joshua, H., Conn, John B., Hirschmann, Ralph, Denkewalter, Robert G.

Journal:

Journal of the American Chemical Society

Year:

1969

Language:

english

File:

PDF, 269 KB

english, 1969

18

Design and Synthesis of Potent Cystine-Free Cyclic Hexapeptide Agonists at the Human Urotensin Receptor

Foister, Shane, Taylor, Laurie L., Feng, Jin-Jye, Chen, Wen-Long, Lin, Atsui, Cheng, Fong-Chi, Smith, Amos B., Hirschmann, Ralph

Journal:

Organic Letters

Year:

2006

Language:

english

File:

PDF, 108 KB

english, 2006

19

Design and synthesis of nonpeptide peptidomimetic inhibitors of renin

Amos B. Smith III, Ryouichi Akaishi, David R. Jones, Terence P. Keenam, Mark C. Guzman, Ryan C. Holcomb, Paul A. Sprengeler, John L. Wood, Ralph Hirschmann, M. Katharine Holloway

Journal:

Year:

1995

Language:

english

File:

PDF, 2.16 MB

english, 1995

20

ChemInform Abstract: A Second-Generation Synthesis of Polypyrrolinone Nonpeptidomimetics: Prelude to the Synthesis of Polypyrrolinones on Solid Support.

Amos B. Smith III, Hu Liu, Ralph Hirschmann

Journal:

Year:

2000

File:

PDF, 34 KB

2000

21

Anterior cruciate ligament reconstruction using quadriceps tendon autograft for adolescents with open physes- a technical note

Christian Mauch, Markus P Arnold, André Wirries, Ralph R Mayer, Niklaus F Friederich, Michael T Hirschmann

Journal:

BMC Sports Science, Medicine and Rehabilitation

Year:

2011

Language:

english

File:

PDF, 1.69 MB

english, 2011

22

First Generation Design, Synthesis, and Evaluation of Azepine-Based Cryptophycin Analogues

Smith, Amos B., Cho, Young Shin, Zawacki, Lisa E., Hirschmann, Ralph, Pettit, George R.

Journal:

Organic Letters

Year:

2001

Language:

english

File:

PDF, 80 KB

english, 2001

23

Investigations of an Antibody Ligase

Smithrud, David B., Benkovic, Patricia A., Benkovic, Stephen J., Taylor, Carol M., Yager, Kraig M., Witherington, Jason, Philips, Barton W., Sprengeler, Paul A., Smith, Amos B., Hirschmann, Ralph

Journal:

Journal of the American Chemical Society

Year:

1997

Language:

english

File:

PDF, 262 KB

english, 1997

24

Synthesis and Binding Affinities of Novel SRIF-Mimicking β- d -Glucosides Satisfying the Requirement for a π-Cloud at C1

Angeles, Angie R., Neagu, Irina, Birzin, Elizabeth T., Thornton, Edward R., Smith, Amos B., Hirschmann, Ralph

Journal:

Organic Letters

Year:

2005

Language:

english

File:

PDF, 202 KB

english, 2005

25

Steroidsby Louis F. Fieser; Mary Fieser

Review by: Ralph Hirschmann

Journal:

American Scientist

Year:

1960

Language:

english

File:

PDF, 354 KB

english, 1960

26

ChemInform Abstract: NONREDUCIBLE CYCLIC ANALOGUES OF SOMATOSTATIN

VEBER, DANIEL F., STRACHAN, ROBERT G., BERGSTRAND, SUSAN J., HOLLY, FREDERICK W., HOMNICK, CARL G., HIRSCHMANN, RALPH, TORCHIANA, MARY LOU, SAPERSTEIN, RICHARD

Journal:

Chemischer Informationsdienst

Year:

1976

File:

PDF, 163 KB

1976

27

Design, Synthesis, and Structural Analysis of d , l -Mixed Polypyrrolinones. 2. Macrocyclic Hexapyrrolinones

Smith, III, Amos B., Xiong, Hui, Charnley, Adam K., Brenner, Meinrad, Mesaros, Eugen F., Kenesky, Craig S., Di Costanzo, Luigi, Christianson, David W., Hirschmann, Ralph

Journal:

Organic Letters

Year:

2010

Language:

english

File:

PDF, 1.45 MB

english, 2010

28

Conformationally Restricted Bicyclic Analogs of Somatostatin

Daniel F. Veber, Frederick W. Holly, William J. Paleveda, Ruth F. Nutt, Susan J. Bergstrand, Marylou Torchiana, Monroe S. Glitzer, Richard Saperstein and Ralph Hirschmann

Journal:

Proceedings of the National Academy of Sciences

Year:

1978

Language:

english

File:

PDF, 880 KB

english, 1978

29

A Partial Synthesis of 11β,17α,21-Trihydroxy-A-nor-3(5)-pregnene-2,20-dione, an A-Nor Homolog of Hydrocortisone

Hirschmann, Ralph, Bailey, G. A., Walker, Robert, Chemerda, John M.

Journal:

Journal of the American Chemical Society

Year:

1959

Language:

english

File:

PDF, 705 KB

english, 1959

30

Die Medizinische Chemie im Goldenen Zeitalter der Biologie: Lehren aus der Steroid- und Peptidforschung

Prof. Dr. Ralph Hirschmann

Journal:

Angewandte Chemie

Year:

1991

Language:

german

File:

PDF, 2.88 MB

german, 1991

31

The first synthesis of a tricyclic homodetic peptide employing coordinated orthogonal protection

Ralph Hirschmann, Wenqing Yao, Byron Arison, Laurie Maechler, Avery Rosegay, Paul A Sprengeler, Amos B Smith III

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 267 KB

english, 1996

32

A General Synthesis of 4,5-Unsaturated 2-Oxasteroids. A Synthesis of 2-Oxacortisol

Hirschmann, Ralph., Steinberg, N. G., Walker, Robert.

Journal:

Journal of the American Chemical Society

Year:

1962

Language:

english

File:

PDF, 1.12 MB

english, 1962

33

Synthesis and Properties of 4-Methyl-2-oxo-1,2-benzopyran-7-yl β-D-Galactoside (Galactoside of 4-Methylumbelliferone)

Strachan, R., Wood, J., Hirschmann, Ralph

Journal:

Journal of Organic Chemistry

Year:

1962

Language:

english

File:

PDF, 258 KB

english, 1962

34

An Orally Bioavailable Pyrrolinone Inhibitor of HIV-1 Protease: Computational Analysis and X-ray Crystal Structure of the Enzyme Complex

Smith, Amos B., Hirschmann, Ralph, Pasternak, Alexander, Yao, Wenquing, Sprengeler, Paul A., Holloway, M. Katharine, Kuo, Lawrence C., Chen, Zhongguo, Darke, Paul L., Schleif, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 295 KB

english, 1997

35

Design and synthesis of peptidomimetic inhibitors of HIV-1 protease and renin. Evidence for improved transport

Smith, Amos B., Hirschmann, Ralph, Pasternak, Alexander, Akaishi, Ryouichi, Guzman, Mark C., Jones, David R., Keenan, Terence P., Sprengeler, Paul A., Darke, Paul L.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 922 KB

english, 1994

36

Inferences about the conformation of somatostatin at a biologic receptor based on NMR studies

Byron H. Arison, Ralph Hirschmann, Daniel F. Veber

Journal:

Bioorganic Chemistry

Year:

1978

Language:

english

File:

PDF, 325 KB

english, 1978

37

Physeal sparing arthroscopic fixation of displaced tibial eminence fractures: a new surgical technique

Michael T. Hirschmann, Ralph R. Mayer, Axel Kentsch, Niklaus F. Friederich

Journal:

Knee Surgery, Sports Traumatology, Arthroscopy

Year:

2009

Language:

english

File:

PDF, 364 KB

english, 2009

38

Somatostatin analogs which define the role of the lysine-9 amino group

RUTH F. NUTT, DANIEL F. VEBER, PAUL E. CURLEY, RICHARD SAPERSTEIN, RALPH HIRSCHMANN

Journal:

Chemical Biology & Drug Design

Year:

1983

Language:

english

File:

PDF, 473 KB

english, 1983

39

The carboxyl terminus heptapeptide of the R2 subunit of mammalian ribonucleotide reductase inhibits enzyme activity and can be used to purify the R1 subunit

Fu-De Yang, Rolando A. Spanevello, Incila Celiker, Ralph Hirschmann, Harvey Rubin, Barry S. Cooperman

Journal:

Year:

1990

Language:

english

File:

PDF, 504 KB

english, 1990

40

Pyrrolinone-Based Peptidomimetics. “ Let the Enzyme or Receptor be the Judge ”

Smith, Amos B., Charnley, Adam K., Hirschmann, Ralph

Journal:

Accounts of Chemical Research

Year:

2011

Language:

english

File:

PDF, 1.54 MB

english, 2011

41

Synthesis of peptides in aqueous medium. VII. Preparation and use of 2,5-thiazolidinediones in peptide synthesis

Hirschmann, Ralph, Dewey, R. S., Schoenewaldt, E. F., Joshua, H., Paleveda, William J., Schwam, H., Barkemeyer, H., Arison, Byron H., Veber, Daniel F.

Journal:

Journal of Organic Chemistry

Year:

1971

Language:

english

File:

PDF, 1.69 MB

english, 1971

42

De novo design and synthesis of somatostatin non-peptide peptidomimetics utilizing .beta.-D-glucose as a novel scaffolding

Hirschmann, Ralph, Nicolaou, K. C., Pietranico, Sherrie, Leahy, Ellen M., Salvino, Joseph, Arison, Byron, Cichy, Maria A., Spoors, P. Grant, Shakespeare, William C.

Journal:

Journal of the American Chemical Society

Year:

1993

Language:

english

File:

PDF, 2.93 MB

english, 1993

43

Peptide bond formation via catalytic antibodies: Synthesis of a novel phosphonate diester hapten

Amos B. Smith III, Carol M. Taylor, Stephen J. Benkovic, Ralph Hirschmann

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 283 KB

english, 1994

44

The Rearrangement of the Steroid C/D Rings 1

Hirschmann, Ralph, Snoddy, C. Stewart, Hiskey, Claude F., Wendler, N. L.

Journal:

Journal of the American Chemical Society

Year:

1954

Language:

english

File:

PDF, 1.56 MB

english, 1954

45

Acetamidomethyl. A Novel Thiol Protecting Group for Cysteine

Veber, Daniel, Milkowski, John, Varga, Sandor, Denkewalter, Robert, Hirschmann, Ralph

Journal:

Journal of the American Chemical Society

Year:

1972

Language:

english

File:

PDF, 882 KB

english, 1972

46

A New Route to 2-Amino-2-deoxy-β-D-glucosides

Strachan, R. G., Ruyle, W. V., Shen, T. Y., Hirschmann, Ralph

Journal:

Journal of Organic Chemistry

Year:

1966

Language:

english

File:

PDF, 447 KB

english, 1966

47

Synthesis of Indomethacin Metabolites

Strachan, R. G., Meisinger, M. A. P., Ruyle, W. V., Hirschmann, Ralph, Shen, T. Y.

Journal:

Journal of Medicinal Chemistry

Year:

1964

Language:

english

File:

PDF, 261 KB

english, 1964

48

A deuterium isotope effect on the inhibition of gastric secretion by N,N-dimethyl-N'-[2-(diisopropylamino)ethyl]-N'-(4,6-dimethyl-2-pyridyl)urea. Synthesis of metabolites

Hoffman, Jacob M., Habecker, Charles N., Pietruszkiewicz, Adolph M., Bolhofer, William A., Cragoe, Edward J., Torchiana, Mary Lou, Hirschmann, Ralph

Journal:

Journal of Medicinal Chemistry

Year:

1983

Language:

english

File:

PDF, 581 KB

english, 1983

49

Dihydrofolate reductase: the amino acid sequence of the enzyme from a methotrexate-resistant mutant of Escherichia coli

Bennett, Carl D., Rodkey, John A., Sondey, John M., Hirschmann, Ralph

Journal:

Year:

1978

Language:

english

File:

PDF, 1.07 MB

english, 1978

50

Development of an Efficient, Regio- and Stereoselective Route to Libraries Based on the β- d -Glucose Scaffold

Hirschmann, Ralph, Ducry, Laurent, Smith, Amos B.

Journal:

Journal of Organic Chemistry

Year:

2000

Language:

english

File:

PDF, 156 KB

english, 2000

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